大家继续探索孤岛的秘密,寻找脱身方法,没想到的是,岛上竟然存在组织严密、早就在此生活的“其他人”。“其他人”将杰克(马修·福克斯 Matthew Fox 饰)、凯特(伊万杰琳·莉莉 Nicole Evangeline Lilly 饰)、索亚(詹姆斯·福特 James F ord 饰)抓进了监狱, 他们设法逃脱,帮助杰克逃脱的是“其他人”中一个叫朱丽叶特的女人(伊丽莎白·米切尔 Elizabeth Mitchell 饰),她跟着杰克来到营地,又揭露了岛上存在过的“达摩计划”,而今“其他人”的领导者本(迈克尔·爱默生 Michael Emerson 饰)正是曾摧毁“达摩计划”的人。朱丽叶特到达营地,似乎带着本赋予她的使命,即带走幸存者中的孕妇……Jack, Kate and Sawyer are kidnapped by "The Others" and put in different environments. Kate has a shower, gets a dress and is invited to have breakfast on the beach with the leader Henry Gale (who identifies himself under his real name of Ben Linus); Sawyer is locked in a cage for wild animals and without food or water, being "awarded" when he hits a lever as if he were an animal; and Jack is locked in a sort of aquarium, being interrogated and controlled by his handler and the Others doctor, Juliet, who has a complete report about his life. Meanwhile, Jack recalls his divorce process with Sarah and how his desperation and rapid meltdown affected everyone around him, including his father.