《玉氏南征记》讲述了一个做事谨慎小心的男人与一个性格急躁的女人之间的有趣故事。Marketing Department Manager, Nam Jung-gi (Yoon Sang-hyun) is so nice that his colleagues call him "Father Theresa" and "Walking UNICEF". There is nothing that can ruffle Jung-gi's feathers but his coworker, Ok Da-jung (Lee Yo-won), who is so nasty tempered she's been nicknamed "Fire Da-jung", and isn't impressed with Jung-gi's affable nature. In fact, his goodness seems to bring out the worst in her, fanning the flames of her fury at everything and everyone. Will Ok Da-jung finally push Nam Jung-gi over the edge and ignite his anger, or will he eventually be the one to cool hers?