一名生活平常受丈夫冷落的女子因一则报上寻人启事,一时突发奇想,而和一名到处惹祸的新潮庞克女郎卷入一场阴错阳差的风波中,又因意外丧失记忆力而展开一连串惊险、紧张、趣味的奇遇。本片声学、制版均系女性,加上二位美丽动人的女主角,是部美国新女性英雄神话式喜剧。Bored Roberta spots a regular personal ad in the paper titled 'Desperately Seeking Susan'. She heads off to New York, following one of the ads, and finds Susan. When Susan sells her jacket, Roberta - trying to emulate her mystery ad writer - buys the jacket and wears it. Little does she know someon is looking for the jacket - and its owner...