在本季首集中,House和Cuddy为上季结尾时的“表白”继续努力--他们希望他们的关系能维持下去。与此同时,普林斯顿教学医院知名的神经外科医生患上疾病,不得不缺席多场手术,威胁到医院作为一级急救中心的信誉。为了尽快治好这名同事,豪斯的医疗组想了很多办法。但他们发现这名同事的 豪斯医生 第七季问题并不仅仅是疾病,还有深层次的原因。他们向豪斯求助,但豪斯一如既往地不予理睬,让他们自己去处理。House and Cuddy are exploring the ramifications of those feelings and attempting to make a real relationship work. Meanwhile, due to a colleague's illness, Princeton Plainsboro is left without a neurosurgeon on site, threatening the hospital's accreditation as a Level 1 Trauma Center. As the team attempts treatment to get their sick colleague back to work, they discover there is more to the illness than they originally suspected and turn to House for direction. Instead, House remains elusive, leaving the team on its own.