美国政府秘密研制的生物武器,巨型蜘蛛"母锁",在联邦号航天飞机上进行注入外星人DNA试验的时候遭遇太阳风暴,发生事故。航天飞机坠毁在地球,"母锁"在很短的时间内变异为高达9米的巨型蜘蛛,四处攻击人类。政府官员玛费和大学生记者马西冲破政府想要隐瞒事实的重重阻挠,不仅向公众披露了政府的所作所为,而且成功地消灭了为害人间的巨型蜘蛛。A DNA experiment on a rare breed of spider is taking place on a NASA space shuttle, when a freak meteor shower engulfs the shuttle, causing everything to go horribly wrong. One survivor is found on the ship and watched over in a secret location deep in the California desert. The problem continues, as the survivor isn't alone, as another deadly spiders climbs out of him and goes on a rampage around the ship. Curious reporter Marci Eyre must now survive, escape and warn everyone before the spider reaches outside the desert.