关押在美梦监狱的X特遣队成员获得一项可以减轻刑罚的新任务,前往南美洲的科托马耳他岛国,摧毁纳粹时期遗留的约顿海姆监狱和实验室,它当前用于关押该国的政治犯并施行人体实验。执行任务期间,X特遣队遭遇巨型外星生物海星斯塔罗,并与它发生冲突。Supervillains Harley Quinn, Bloodsport, Peacemaker and a collection of nutty cons at Belle Reve prison join the super-secret, super-shady Task Force X as they are dropped off at the remote, enemy-infused island of Corto Maltese.