Frank Johnson flees police after becoming an eyewitness to murder. He is pursued around scenic San Francisco by his wife, a reporter, the police, and... the real murderer.Frank Johnson (Ross Elliott), sole witness to a gangland murder, goes into hiding and is trailed by Police Inspector Ferris (Robert Keith), on the theory that Frank is trying to escape from possible retaliation. Frank's wife, Eleanor (Ann Sheridan), suspects he is actually running away from their unsuccessful marriage. Aided by a newspaperman, Danny Leggett (Dennis O'Keefe), Eleanor sets out to locate her husband. The killer is also looking for him, and keeps close tabs on Eleanor.