假期到来,就读于路易斯安那州立大学的戴维(理查德·考恩克 Richard Kohnke 饰)、泰勒(凯拉·埃维尔 Kayla Ewell 饰)、布莱斯(艾斯利·布莱恩 Ashlee Brian 饰)、诺美(布瑞特妮·埃尔格 Brittney Alger 饰)和莎莉(沙拉·巴特勒 Sarah Butler 饰)相约来到公子哥同学霍华德(迈克·韦尔什 Michael Welch 饰)家的豪华别墅度假。正当他们沉浸在无上的快乐中时,突然得知导弹向美国本土袭来的惊人消息。在危机当前,几名青年经过讨论决定暂时留在别墅中,相机而动。未及,一枚导弹在附近炸毁,危机似乎就此结束。 但是新的危险随之到来,周围好像一夜之间变成恐怖丧尸的世界。大批丧失人性、嗜血如命的活死人接二连三向年轻人们袭来,死神露出狰狞的笑容……In Baton Rouge, Louisiana, Taylor, her boyfriend David and their friends Brice and his girlfriend Naomi travel together on vacation to spend a couple of days with their friends Sharley and her boyfriend Howard in the house of his family. On the next day, they see a missile exploding near the house and soon they learn that the USA is under a biological terrorist attack. Out of the blue, a hostile dog comes to the real estate and they decide to lock the door and go sleep. On the next morning, the dog is still stalking them and Brice kills it with a baseball bat. David decides to take the dog to the CDC and he discovers that the locals have transformed in sort of zombies. The friends are attacked by these zombies and have to find a means to escape and survive the hordes of zombies. Will they survive?