美国海军陆战队法兰(艾德•哈里斯 Ed Harris 饰)将军因不满政府对退伍、战死军人及其家属的补偿和福利不满,率领部下将美军最新研制的生化武器――VX毒气弹――偷运到罗克岛,劫持了81名正在该岛观光的游客,控制了该岛。要挟美国政府48小时内支付1亿元赎金否则将杀死人质并用毒气弹袭击旧金山。 罗克岛之前曾是美国防卫最严密的监狱,易守难攻。美国政府偶然从档案中发现前英国特工梅森(肖恩•康纳利 Sean Connery 饰)曾顺利从该监狱出逃,于是他们请来了梅森,要求他30小时之内带领特种部队攻占这座“魔鬼岛”……Stanley Goodspeed, who lives in Washington D.C., is a biochemist who works for the FBI. Soon after his fiancée Carla Pestalozzi announces that she is pregnant, Stanley gets a call from FBI director James Womack. Womack tells Stanley that San Francisco's Alcatraz Island has been taken hostage, along with 81 tourists, by marine General Francis Xavier Hummel who, for years, has been protesting the government's refusal to pay benefits to families of war veterans who died during covert military operations. The death of his wife Barbara Hummel on March 9, 1995 drove General Hummel over the edge, and now he's holding hostages in order to get his point across. Stanley is needed because General Hummel has stolen some VX gas warheads and has announced that he will launch them onto San Francisco unless his demands are met. Stanley knows how to disarm the bombs, but Stanley needs someone who knows Alcatraz well enough to get him inside. That man is former British intelligence agent John Patrick Mason, who has been in prison for the past 30 years without a trial because he was accused of stealing the private files of J. Edgar Hoover. In 1962, John became the only inmate ever to escape from Alcatraz, and he stayed out of Alcatraz long enough to father a daughter named Jade Angelou. Despite his extreme hatred of the FBI, John agrees to help Stanley. When John and Stanley are sent into Alcatraz with a Navy SEAL team, General Hummel's men kill the entire SEAL team, leaving Stanley and John to work on their own to rescue the hostages.