21世纪初,一场瘟疫夺去了99%的人类生命,幸存者们依靠科学家古德查德的发明,建造孤城布瑞拉格维系文明。时间过去四百年后,部分市民不满古德查德政权独裁统治与持续发生的失踪案,组建武装力量魔力党(Monicans)对抗。 女战士伊恩(查理兹·塞隆 Charlize Theron 饰)是魔力党中实力顶尖的人物,在完成破坏古德查德监控系统的任务中,伊恩目睹了被对方杀害的亲妹遗体,伊恩在怒火添胸时得到了刺杀古德查德首脑特雷弗的指令,但当她与特雷弗面对面时,对方呼唤“凯瑟琳”这个名字让她陷入混乱的记忆无法行动。伊恩脱身后着手调查这座城市的真相,发现一直以来的失踪案与克隆计划息息相关,而布瑞拉格运行的基础便是复制人类。伊恩的发现很快引起连锁反应,将各方势力卷入其中……400 years in the future, set in the year 2415, Aeon Flux is a mysterious assassin. Four centuries after a virus nearly annihilated the human race, leaving only five million survivors in a utopian city called Bregna. Aeon is struggling to destroy the Goodchild regime led by its namesake, Trevor Goodchild, the ruler of Bregna and a descendant of the man who found a cure for the deadly virus. As instructed by the Handler, Aeon is assigned to assassinate Goodchild, but there are deeper secrets to be discovered, and conspiracies to be foiled.