19世纪上半叶,后来在美国历史上留下重要足迹的亚伯拉罕·林肯(本杰明·沃克 Benjamin Walker 饰)还只是一个背负着杀母仇恨的年轻人。在一个充满不祥气息的夜晚,他举枪刺杀了仇人,但已经遭受了致命伤的仇家却凶恶反扑。关键时刻,林肯被名叫亨利·斯特吉斯(多米尼克· 库伯 Dominic Cooper 饰)的男人所救。从亨利口中得知,他险些被变成吸血鬼的仇家杀害。经过一番艰苦特训,林肯成为吸血鬼猎人。正值此时,吸血鬼业已蔓延整个美国南部,并渐次向北方推进。 在亨利的指示下,林肯返回城镇,展开了针对吸血鬼似乎永无止境的猎杀,而吸血鬼制造者杰克·巴兹(Marton Csokas 饰)也注意到了这名“索命死神”的存在……At the age of 9, Abraham Lincoln witnesses his mother being killed by a vampire, Jack Barts. Some 10 years later, he unsuccessfully tries to eliminate Barts but in the process makes the acquaintance of Henry Sturgess who teaches him how to fight and what is required to kill a vampire. The quid pro quo is that Abe will kill only those vampires that Henry directs him to. Abe relocates to Springfield where he gets a job as a store clerk while he studies the law and kills vampires by night. He also meets and eventually marries the pretty Mary Todd. Many years later as President of the United States, he comes to realize that vampires are fighting with the Confederate forces. As a result he mounts his own campaign to defeat them.